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SYNMR N-Phenethyldimethylamine Citrate / Eria Jarensis: The Purest. The Best.

 

The supplement industry is an industry of transient favorites. It feels as though every time we agree on an ingredient; it disappears to time. With the passing of fan favorite stimulants like DMAA and market trust issues with DMHA, customers are forced to find comfort in the saving grace of a new effective stimulant. Could the latest and greatest come from orchids?!

 

Here at SYNMR, we think so -- and our ingredient, known as N-Phenethyldimethylamine Citrate (sometimes labeled as Eria Jarensis Extract or shortened to N,N-DMPEA) -- is the next big thing.


Below, we discuss uses for this ingredient, SYNMR's quality statements, and then the science behind the ingredient itself and its mechanisms of actions.

Incredible in Fat Burners, Pre Workouts, Nootropics, and Mood Enhancers

Our N-Phenethyldimethylamine Citrate provides a euphoric, mood-enhancing stimulation that is unparalleled on the market today, especially given the recent regulatory issues concerning competing stimulants.

 

This ingredient is often used alongside caffeine, and makes for an incredible workout supplement, since it gets users in the mood to train hard. It is also effective in fat burners, helping to improve mental status during difficult caloric deficits. Some even say that the ingredient helps suppress appetite!

 

Used alongside other cognitive-enhancers, N-Phenethyldimethylamine Citrate can help separate your nootropic supplement from the pack, since many on the market do not have a PEA-based compound like this.

 

There are other great uses for N,N-DMPEA, and the sky is the limit when you formulate using SYNMR!

 

SYNMR Provides Perfect Service

 

We provide customers with both HPLC and MS charts, COA, and the most pure N,N-DMPEA on the market.

 

We use the Citrate form of N-Phenethyldimethylamine, which is more shelf-stable and has no discernible odor. Don't trust the competing forms of this ingredient, they will clump and melt, but "Eria Jarensis Citrate" will outlast them!

 

Now it is time to discuss the ingredient itself.

Introduction: Why we developed our N-Phenethyldimethylamine Citrate

Ever since Ephedrine ban in 2006, the supplement industry has been working to replace it with a new universally loved stimulant.[1] The search for an ephedrine replacement started a saga of ingredient innovation that persists to this day. Perhaps the best known “replacement” was DMAA — an apparent plant-based constituent[2] that is no longer accepted on the US market. Made famous by the legendary pre-workout JACK3d — DMAA had lifters hitting new PRs and losing weight better than ever. DMAA was short-lived and found itself on the receiving end of the FDA’s legal action hammer.

 

After DMAA’s time, everyone fell in love with Dendrobium extract… until we found out that the company that made it popular spiked their main product using this extract with a methamphetamine analogue. Perhaps even worse, the product’s ingredient makeup didn’t match the product’s own marketing.[3] Dendrobium extract then fell to the wayside. The industry found new comfort in AMP Citrate (sometimes labeled as DMBH) — as it reminded many of the DMAA-rush they all had loved. Unfortunately, it had practically no basis in nature, so it was not considered a "constituent of a botanical", and as expected, the FDA acted swiftly and mercilessly.[4]

 

What's next?

 

So you get the point... the industry is constantly trying to replace DMAA and ephedrine. Eria jarensis extract is a child of the new demand for industry innovation — and is one of the most popular stimulants on the market as of recent years, subject to no FDA action as of early 2019. Now, we get to the crux of this article... why should we care about another plant extract?

What is Eria Jarensis?

Eria jarensis is a member of the Eria genus, a massive genus of orchids that has over 500 species found across Asia. While the Eria family may be aesthetic, this is no claim to fame. Jarensis stands above its siblings as it contains an alkaloid known as N, N-dimethylphenethyldimethylamine.[5] For a refresher, an alkaloid is a group of organic compounds that all have nitrogen atoms. To connect this to a real world construct, synephrine is an alkaloid extracted from the Citrus Aurantium fruit — better known as Bitter orange.

 

Now that we have a basis in nature settled, can get to the N,N-dimethylphenethylamine (N,N-DMPEA) information. First off, we disclose that alkaloids vary from one to another. While morphine is an alkaloid — it doesn’t mean that all alkaloids are depressants. In fact, PEA is the perfect example of how different alkaloids can be. While morphine is a painkiller, PEA is a mood booster. For the mechanism below to make sense — please note that trace amines like PEA are naturally-occurring.

Wait, How? The First Punch

The constituent of N,N-DMPEA is phenethylamine — a molecule better known to athletes and scientists alike as PEA. PEA interacts with the central nervous system and may bolster dopamine levels.[6] Dopamine is a "feel good" neurotransmitter and may be behind the mood boosting qualities of PEA supplementation. However, this effect is short-lived and falls off within minutes as monoamine oxidase (the MAO enzyme) rapidly breaks PEA down.[7-10]

 

Let’s get into some fun research. There is evidence suggesting that N,N-DMPEA acts as a trace amine-associated receptor 1 agonist — which we’ll call it TAAR1 from now on.[11-12] TAAR1 is a receptor that amphetamine, methamphetamine, dopamine, and other amines act upon.[13,14] All of these agonists help raise levels of cAMP (Cyclic adenosine monophosphate) inside a cell — which influences intracellular changes.[11-13] While we wish we could give you one effect of TAAR1 — it has many effects that are site specific.

 

However, we know TAAR1 increases the amount of monoamines inside neural synapses. Monoamines include the friend we mentioned — dopamine.[14] This is likely why lifters report feeling so good on PEA. The monoamine family also includes epinephrine and norepinephrine which leads us to infer that PEA could be ergogenic.

The Second Punch

This whole TAAR1 mechanism is like the “heavy lifting” part of PEA. However, N,N-DMPEA also acts as a serotonin agonist of the 5H1A receptor subtype. Activation of 5-HT1A creates many feel good effects ranging from decreased aggression, increased sociability, inhibition of drug seeking behavior, an increase in sex drive, and even diminished food intake.[18-22]

 

Interestingly, there are many marketed 5HT1A agonists — ranging from therapeutic drugs like buspar all the way to methylphenidate. Yes — this is another receptor that N,N-DMPEA shares in common with many feel-good drugs we know and love. No wonder PEA feels so good… it‘d be surprising if it didn’t!

How Should We Dose It? Are There Side Effects? Any Warnings?

Dosing for N,N-DMPEA is still unexplored territory in terms of sports performance research. We would state that an absolute maximum dose would be around 125mg twice per day for new users. We created this recommendation by reviewing products that have used N,N-DMPEA in the past to great success.

 

It is too early to tell if they’re any long-term effects of chronic N,N-DMPEA usage. Users have reported rapid heartbeat and high blood pressure in high enough doses. Despite this, monoamine oxidase breaks N-N-DMPEA down so rapidly that it would be difficult to reproduce and measure in a clinical trial.

 

However, we would not use PEA supplements with monoamine oxidase inhibitors. Many pharmaceutical drugs act as monoamine oxidase inhibitors. If you take such a medication, consult your doctor before you even consider buying N-N-DMPEA. Beyond this safety warning, we will disappoint readers by warning observation that N,N-DMPEA isn’t as intense as DMAA. For the stimulant junkies out there, N,N-DMPEA might not scratch that itch DMAA left behind.

Won’t This Just Get Banned Next?

The chances of N,N-DMPEA getting banned are slim. This is because of N,N-DMPEA’s status as a generally recognized as safe (GRAS) food additive. The FDA itself maintains a database titled Substances Added to Food — and they list N,N-DMPEA! This database contains all ingredients that in food production that the FDA considers safe for consumption. N,N-DMPEA even has its own page which can be found here. [23]The World Health Organization also considers N,N-dimethyl-phenethylamine safe, further protecting it from the law. [24]

Where Do We Get It?

Like anything in the supplement industry, the quality of product depends on the lab that’s producing it. The most responsive supplier of N,-N-DMPEA by far is SYMNR, who provided us with HPLC, HNMR, AND MS tests to prove the purity of their extract. They claim to have the most pure N,N-PEA on the market AND they proved it!

 

I say we use the same graphs they gave us in the OG article right around here.

Conclusion

If you’re a brand looking to secure N,N-DMPEA in a new product, you can contact SYNMR directly on their website as they are highly responsive. As of 2019, SYMR would be our go-to-recommendation for brands looking to use N,N-DMPEA or even if a citizen of PricePlow nation is trying to buy feel-good vibes in bulk.

 

 

References

1. Nutraceutical Corporation vs. FDA; Appeal from the United States District Court for the District of Utah. (2006). Retrieved from https://www.ca10.uscourts.gov/opinions/05/05-4151.pdf

2. Li, J. S., Chen, M., & Li, Z. C. (2012). Identification and quantification of dimethylamylamine in geranium by liquid chromatography tandem mass spectrometry. Analytical chemistry insights, 7, 47-58.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422085/

3. Muscles and Meth: Drug Analog Identified in ‘Craze’ Workout Supplement. (2014, October). Retrieved from https://www.wiley.com/WileyCDA/PressRelease/pressReleaseId-109679.html

4. Center for Food Safety and Applied Nutrition. (2017). Products & Ingredients - DMBA in Dietary Supplements. Retrieved from https://www.fda.gov/Food/DietarySupplements/ProductsIngredients/ucm444719.htm

5. Hedman, K., Leander, K., Lüning, B., Steen, G. O., Chan, R. P., & Craig, J. C. (1969). Studies on Orchidaceae Alkaloids. XV. Phenethylamines from Eria jarensis Ames. Acta Chemica Scandinavica, 23, 3261-3261; http://actachemscand.org/pdf/acta_vol_23_p3261.pdf 

6. Narang, D., Tomlinson, S., Holt, A., Mousseau, D., & Baker, G. (2017). Trace amines and their relevance to psychiatry and neurology: A brief overview. Klinik Psikofarmakoloji Bulteni-Bulletin Of Clinical Psychopharmacology, 1. https://www.researchgate.net/publication/271188579_Trace_Amines_and_Their_Relevance_to_Psychiatry_and_Neurology_A_Brief_Overview

7. Phenethylamine. (2018). Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/1001?from=summary#section=Biological-Half-Life

8. Shannon, H. E., Cone, E. J., & Yousefnejad, D. (1982, October). Physiologic effects and plasma kinetics of beta-phenylethylamine and its N-methyl homolog in the dog. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/7120117

9. Suzuki, O., Katsumata, Y., & Oya, M. (1981). Oxidation of ?-Phenylethylamine by Both Types of Monoamine Oxidase: Examination of Enzymes in Brain and Liver Mitochondria of Eight Species. Journal of Neurochemistry, 36(3), 1298-1301. https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1471-4159.1981.tb01734.x

10. Yang HY, Neff NH. (1973) Beta-phenylethylamine: a specific substrate for type B monoamine oxidase of brain. J Pharmacol Exp Ther 187:365-371; http://jpet.aspetjournals.org/content/187/2/365.long

11. Berry, M. D., Gainetdinov, R. R., Hoener, M. C., & Shahid, M. (2017). Pharmacology of human trace amine-associated receptors: Therapeutic opportunities and challenges. Pharmacology & Therapeutics, 180, 161-180. https://www.ncbi.nlm.nih.gov/pubmed/28723415

12. Wainscott, D. B., Little, S. P., Yin, T., Tu, Y., Rocco, V. P., He, J. X., & Nelson, D. L. (2006). Pharmacologic Characterization of the Cloned Human Trace Amine-Associated Receptor1 (TAAR1) and Evidence for Species Differences with the Rat TAAR1. Journal of Pharmacology and Experimental Therapeutics, 320(1), 475-485; http://jpet.aspetjournals.org/content/320/1/475.short

13. Grandy, D. K., Miller, G. M., & Li, J. (2016). “TAARgeting Addiction”—The Alamo Bears Witness to Another Revolution. Drug and Alcohol Dependence, 159, 9-16; https://ohsu.pure.elsevier.com/en/publications/taargeting-addiction-the-alamo-bears-witness-to-another-revolutio 

14. Miller, G. M. (2010). The emerging role of trace amine-associated receptor 1 in the functional regulation of monoamine transporters and dopaminergic activity. Journal of Neurochemistry,116(2), 164-176; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005101 

15. Borowsky B, Adham N, Jones KA, et al. (2001) Trace amines: identification of a family of mammalian G protein-coupled receptors. Proc Natl Acad Sci USA 98:8966-8971; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC55357 

16. Bunzow JR, Sonders MS, Arttamangkul S, et al. (2001) Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor. Mol Pharmacol 60:1181-1188; http://molpharm.aspetjournals.org/content/60/6/1181.long

17. Lindemann L, Ebeling M, Kratochwil NA, et al. (2005) Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors. Genomics 85:372-385; https://www.ncbi.nlm.nih.gov/pubmed/1571810 

18. Boer SF, Koolhaas JM (2005). "5-HT1A and 5-HT1B receptor agonists and aggression: a pharmacological challenge of the serotonin deficiency hypothesis". Eur. J. Pharmacol; https://www.ncbi.nlm.nih.gov/pubmed/1631018 

19. Thompson MR, Callaghan PD, Hunt GE, Cornish JL, McGregor IS (May 2007). "A role for oxytocin and 5-HT(1A) receptors in the prosocial effects of 3,4 methylenedioxymethamphetamine ("ecstasy")". Neuroscience; https://www.ncbi.nlm.nih.gov/pubmed/17383105

20. Müller CP, Carey RJ, Huston JP, De Souza Silva MA (2007). "Serotonin and psychostimulant addiction: focus on 5-HT1A-receptors". Prog. Neurobiol; https://www.ncbi.nlm.nih.gov/pubmed/17316955

21. Fernández-Guasti A, Rodríguez-Manzo G (January 1997). "8-OH-DPAT and male rat sexual behavior: partial blockade by noradrenergic lesion and sexual exhaustion". Pharmacol. Biochem. Behav; https://www.ncbi.nlm.nih.gov/pubmed/898161 

22. Ebenezer IS, Arkle MJ, Tite RM (2007). "8-Hydroxy-2-(di-n-propylamino)-tetralin inhibits food intake in fasted rats by an action at 5-HT1A receptors". Methods Find Exp Clin Pharmacol; https://www.ncbi.nlm.nih.gov/pubmed/17609739

23. Center for Food Safety and Applied Nutrition. (2019). Ingredients & Packaging - Substances Added to Food (formerly EAFUS). Retrieved from https://www.fda.gov/food/ingredientspackaginglabeling/ucm115326.htm

24. World Health Organization. (2006). EVALUATION OF CERTAIN FOOD ADDITIVES. Retrieved from https://apps.who.int/iris/bitstream/handle/10665/43408/WHO_TRS_934_eng.pdf;jsessionid=2E405EE5D0771C1AF0455E7D90CB49E1?sequence=1

 

 

 

 

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